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FBXW12 Antibody, Biotin conjugated

Datasheet
Code CSB-PA751062LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXW12 Polyclonal antibody
Uniprot No.
Q6X9E4
Target Names
FBXW12
Alternative Names
FBXW12 antibody; FBW12 antibody; FBXO12 antibody; FBXO35F-box/WD repeat-containing protein 12 antibody; F-box and WD-40 domain-containing protein 12 antibody; F-box only protein 35 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box/WD repeat-containing protein 12 protein (1-250AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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FBXW12 Antibodies

FBXW12 Proteins

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Target Background

Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Gene References into Functions
  1. FBXW12 gene is deleted in approximately ten percent of the epithelial ovarian cancer cases studied; such deletions comprised either the FBXW12 promoter or the mRNA-encoding region. PMID: 26617728
  2. FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R and that therapeutic FBXW12 inhibition may enhance IL-22 signaling and bolster mucosal host defense and infection containment. PMID: 26171402
  3. FBXO35 gene had a ubiquitously low expression pattern in most human adult tissues. FBXO35 gene was found located in chromosome 3p21. PMID: 15040455
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 20729

OMIM: 609075

KEGG: hsa:285231

STRING: 9606.ENSP00000296438

UniGene: Hs.288793

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